rheumatoid arthritis animal models ppt

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Animal models for rheumatoid arthritis Collagen-induced arthritis CIA CIA in DBA1 mice with non-self type II collagen Development of chronic CIA in C57Bl mice Development of CIA in mice with black background Erosive arthritis in a DBA1 mouse with CIA 1 Erosive arthritis in a DBA1 mouse with CIA 2 Different disease phases of chronic CIA. Rheumatoid arthritis RA is a chronic inflammatory autoimmune disease influenced by both genetic and environmental factors.

Investigating Mtx Loaded Magnetic Nanocomposite Particles For Treatment Of Rheumatoid Arthritis Sciencedirect

The development of novel treatments for rheumatoid arthritis RA requires the interplay between clinical observations and studies in animal models.

. Rheumatoid arthritis Animal models Drug therapy Biologics 1. Rheumatoid arthritis-associated interstitial lung disease ra-ild is a systematic autoimmune disease characterized by joint lesions 1 and diffuse interstitial pulmonary changes 2 accompanying poor prognosis. Rheumatoid arthritis RA is a chronic inflammatory disorder characterized by synovitis and joint damage.

Important differences include 1 animal models of RA progress much more rapidly than does human disease and thus are characterized by primarily acute inflammatory responses and 2 rodents have a. Ii in AIA models mice are first immunised with an unrelated antigen in the presence of an adjuvant and then rechallenged with the same antigen in the joint. Animal models of rheumatoid arthritis Bina Joe and Ronald L.

Commonly used animal models in terms of their pathological similarities to human rheumatoid arthritis as well as their response to drug therapy. Disease models MOLECULAR MEDICINE TODAY AUGUST 1999 VOL. B-cell depletion inhibits arthritis in a collagen-induced arthritis CIA model but does not adversely affect humoral responses in a respiratory syncytial virus RSV vaccination model.

Introduction RA is a chronic systemic autoimmune disorder causing a symmetrical polyarthritis. Current ra animal models are highly reproducible and of short duration having similar patterns to those occurring in human disease although they present some differences such as 1 faster progression of the disease characterized by an acute inflammatory response and 2 rodents have a tendency to marked resorption and bone formation. In general the ability of animal models to predict efficacy of biologics in man has been good.

AGE and SEX in AR 5. Blood 106 2005 pp. Epidemiology RA affects 051 of the population world-wide with a peak prevalence between the ages of 30 and 50 years.

There is a critical need for better and well-defined animal models for rheumatoid arthritis RA that display the specific aspects of the human disease and can serve as platforms for research on the underlying pathology as well as for drug discovery and validation 12Currently collagen type II-induced arthritis CIA in mice and rats and adjuvant arthritis. Two new models for the study of rheumatoid arthritis have been established. Introduction Animal models of arthritis have been used extensively to test identify drug targets for rheumatoid arthritis RA and test potential therapeutics.

The establishment and application of animal models represent effective tools for research in rheumatoid arthritis pathogenesis andApplication of these experimental disorders for testing potential therapeutic approaches will help to make better predictions for drug efficiency in human RA. The etiology of RA is multi-factorial including. The discovery of this model led to cules a ra-related human auto-anti- genetically manipulated several studies investigating titers of genic protein hcgp-39 and a tcr spontaneous arthritis models pathogenic anti-glucose-6-phosphate tcr-ab transgene specific for an isomerase antibodies in ra patients.

These models may employ the use of TCR transgenic T cells. Arthritis involving three or more joints. 1 Highly Influenced PDF View 14 excerpts.

However the predictive power of animal models for small molecules has been variable probably because of. VLokeesan BSN TAssistant lecturer FHCSEUSL. Comparison of rat and mouse models of erosive arthritis to rheumatoid arthritis RA in humansa Model Similarities to human disease Differences from human disease.

Arthritis pain in human patients Rheumatoid arthritis RA and spondyloarthritis are prevalent inflammatory-erosive joint diseases which affect as many as 2 of the population worldwide causing severe debilitating morbidity and major economic costs due to both health care expenditures and lost productivity. Severity of and susceptibility to RA are influenced by multiple genetic reproductive age and environmental factors. Given the complex molecular pathogenesis and highly heterogeneous clinical picture of RA there is an urgent.

SCID severe combined immunodeficient mice implanted with human synovial tissues and human HLA-DR4-CD4 transgenic mice represent novel and important approaches to the use of animal models in pathogenetic studies. Constitutional symptoms such as fatigue malaise morning stiffness are common RHEUMATOID ARTHRITIS 4. Experimental animal models of arthritis including type II collagen-induced arthritis proteoglycan-induced arthritis adjuvant arthritis pristane-induced arthritis and streptococcal cell wall-induced arthritis have contributed to recent advances in the understanding of the immunopathology of arthritis.

The classic clinical picture is characterized by symmetric polyarthritis interesting both hands with morning stiffness lasting more than 1 hour. Autoimmune disease rheumatoid arthritis animal models biomarkers 1 1. However the genetic divergences between rodents and humans determine differences in the development of RA which makes it necessary to explore.

5 368 Table 1. Rheumatoid arthritis 1. Introduction Traditionally the immune system has been considered as a set of structures molecules cells and specialized tissues and biological processes responsible for the defense against aggression by a.

I CIA mice are injected with heterologous or autologous collagen in the presence of an adjuvant. CIA and AIA models of arthritis. Rheumatoid arthritis Rat model Mouse model Rheumatoid arthritis RA is a very common autoimmune disease that is characterized by the chronic progressive symmetrical and erosive destruction of peripheral joints.

Important hcgp-39 epitope allowed. 3 - 5 the possibility of developing ra-ild increases over time after diagnosis of rheumatoid arthritis ra and the median survival of. At present rodent models are primarily used to study the pathogenesis and treatment of RA.

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